Purinergic receptors P2Y12R and P2X7R: potential targets for PET imaging of microglia phenotypes in multiple sclerosis.

Wissam BeainoBieneke JanssenGijs KooijSusanne M A van der PolB van Het HofJack van HorssenAlbert D WindhorstHelga E de Vries

Published in: Journal of neuroinflammation (2017)

Our results suggest that P2Y12R and P2X7R are excellent targets for PET imaging to discriminate distinct microglia phenotypes in MS. Ultimately, this may provide insight into the role of microglia in disease progression and monitor novel treatment strategies to alter microglia phenotype.

Keyphrases

pet imaging
multiple sclerosis
inflammatory response
neuropathic pain
positron emission tomography
mass spectrometry
spinal cord
ms ms
computed tomography
climate change