Brain function distinguishes female carriers and non-carriers of familial risk for autism.

Adam T EggebrechtAlly DworetskyZoë HawksRebecca CoalsonBabatunde AdeyemoSavannah DavisDaniel GrayAlana McMichaelSteven E PetersenJohn N ConstantinoJohn R Pruett

Published in: Molecular autism (2020)

These methods confirmed pronounced neural signatures that differentiate brain responses to biological and scrambled motion. Our sample of undiagnosed females enriched for family genetic loading enabled discovery of numerous contrasts between carriers and non-carriers of risk of ASD that may index variations in visual attention and motion processing related to genetic susceptibility and inform our understanding of mechanisms incurred by inherited liability for ASD.

Keyphrases

autism spectrum disorder
genome wide
intellectual disability
white matter
attention deficit hyperactivity disorder
small molecule
high speed
working memory
early onset
high throughput
high resolution
blood brain barrier
subarachnoid hemorrhage