Mitochondrial Transfer as a Novel Therapeutic Approach in Disease Diagnosis and Treatment.
Vicente Javier Clemente-SuarezAlexandra Martín-RodríguezRodrigo Yáñez-SepúlvedaJose Francisco Tornero AguileraPublished in: International journal of molecular sciences (2023)
Mitochondrial dysfunction is a hallmark of numerous diseases, including neurodegenerative disorders, metabolic disorders, and cancer. Mitochondrial transfer, the transfer of mitochondria from one cell to another, has recently emerged as a potential therapeutic approach for restoring mitochondrial function in diseased cells. In this review, we summarize the current understanding of mitochondrial transfer, including its mechanisms, potential therapeutic applications, and impact on cell death pathways. We also discuss the future directions and challenges in the field of mitochondrial transfer as a novel therapeutic approach in disease diagnosis and treatment.