Influence of efavirenz and 8-hydroxy-efavirenz plasma levels on cognition and central nervous system side effects.

Alice RanzaniFrancesco CastelliAntonio Di BiagioAntonella d'Arminio MonforteAntonio D'AvolioAlessandro SoriaFrancesca BaiEmanuele Foca'Lucia TaramassoAndrea CalcagnoElena BrescianiAntonio TorselloPaolo BonfantiGiuseppe Lapadula

Published in: HIV medicine (2023)

Higher levels of 8-OH-EFV were associated with CNS side effects, while EFV levels were only marginally associated with cognitive performance, thus suggesting that EFV and its metabolite may act differently in determining detrimental neurological effects.

Keyphrases

hiv infected
antiretroviral therapy
hiv infected patients
mild cognitive impairment
blood brain barrier
cerebrospinal fluid
multiple sclerosis
brain injury