Cerebrospinal fluid biomarkers for Alzheimer's and vascular disease vary by age, gender, and APOE genotype in cognitively normal adults.
Ge LiJane B ShoferEric C PetrieChang-En YuCharles W WilkinsonDianne P FiglewiczAndrew Shutes-DavidJing ZhangThomas J MontineMurray A RaskindJoseph F QuinnDouglas R GalaskoElaine R PeskindPublished in: Alzheimer's research & therapy (2017)
Female APOE-ε4 carriers appear at higher risk for AD after age 50. In contrast, men may experience a relatively higher rate of cerebrovascular injury in middle and early old age.