Genetically predicted circulating concentrations of micronutrients and risk of colorectal cancer among individuals of European descent: a Mendelian randomization study.
Konstantinos K TsilidisNikos PapadimitriouNiki DimouDipender GillSarah J LewisRichard M MartinNeil MurphyGeorgios MarkozannesVerena ZuberAmanda J CrossKimberley BurrowsDavid S LopezTimothy J KeyRuth C TravisAurora Perez-CornagoDavid J HunterFränzel J B van DuijnhovenDemetrios AlbanesVolker ArndtSonja I BerndtStéphane BézieauD Timothy Timothy BishopJuergen BoehmHermann BrennerAndrea Burnett-HartmanPeter T CampbellGraham CaseySergi Castellví-BelAndrew T ChanJenny Chang-ClaudeAlbert de la ChapelleJane C FigueiredoSteven J GallingerGraham G GilesPhyllis J GoodmanAndrea GsurJochen HampeHeather HampelMichael HoffmeisterMark A JenkinsTemitope O KekuSun-Seog KweonSusanna C LarssonLoic Le MarchandChristopher I LiLi LiAnnika LindblomVicente MartínJonathan BeesleyVictor MorenoHongmei NanRami NassirPolly A NewcombKenneth OffitPaul D P PharoahElizabeth A PlatzJohn D PotterLihong QiGadi RennertLori C SakodaClemens SchafmayerMartha L SlatteryLinda SnetselaarJeanette SchenkStephen N ThibodeauCornelia M UlrichBethany Van GuelpenSophia HarlidKala VisvanathanLudmila VodickovaHansong WangEmily WhiteAlicja WolkMichael O WoodsAnna H WuQuan LongBas Bueno-de-MesquitaMarie-Christine Boutron-RuaultDavid J HughesPaula JakszynTilman KühnDomenico PalliElio RiboliEdward L GiovannucciBarbara L BanburyStephen B GruberUlrike PetersMarc J GunterPublished in: The American journal of clinical nutrition (2021)
These results suggest possible causal associations of circulating iron and vitamin B-12 (positively) and selenium (inversely) with risk of colon cancer.
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