Simvastatin, edaravone and dexamethasone protect against kainate-induced brain endothelial cell damage.

Lilla BarnaFruzsina R Walter András HarazinAlexandra BocsikAndrás KincsesVilmos TubakKatalin JósvayÁgnes ZvaraPatricia Campos-Bedolla Mária A Deli

Published in: Fluids and barriers of the CNS (2020)

Kainate directly damaged cultured brain endothelial cells. Simvastatin, edaravone and dexamethasone protected the BBB model against kainate-induced changes. Our results confirmed the potential clinical usefulness of these drugs to attenuate BBB damage.

Keyphrases

endothelial cells
high glucose
oxidative stress
diabetic rats
blood brain barrier
resting state
low dose
white matter
drug induced
vascular endothelial growth factor
functional connectivity
multiple sclerosis
climate change