Plasma microRNA-320c as a Potential Biomarker for the Severity of Knee Osteoarthritis and Regulates cAMP Responsive Element Binding Protein 5 (CREB5) in Chondrocytes.

Rongwei ZhouLike Zhao Qian Wang Yongjing Cheng Miao Song Cibo Huang

Published in: Disease markers (2024)

Our results indicate that plasma miR-320c may serve as a potential novel predictor of the severity of knee OA and that miR-320c may play an important role in the pathogenesis of OA through inhibiting the cAMP pathway by targeting CREB5.

Keyphrases

knee osteoarthritis
binding protein
cell proliferation
long non coding rna
long noncoding rna
signaling pathway
protein kinase
total knee arthroplasty
risk assessment
climate change