The tryptophan catabolite or kynurenine pathway in COVID-19 and critical COVID-19: a systematic review and meta-analysis.

Abbas F AlmullaThitiporn SupasitthumrongChavit TunvirachaisakulAli Abbas Abo AlgonHussein K Al-HakeimMichael Maes

Published in: BMC infectious diseases (2022)

Our results indicate increased activity of the IDO enzyme in COVID-19 and severe/critical patients. The TRYCAT pathway is implicated in the pathophysiology and progression of COVID-19 and may signal a worsening outcome of the disease.

Keyphrases

coronavirus disease
sars cov
end stage renal disease
respiratory syndrome coronavirus
chronic kidney disease
early onset
peritoneal dialysis
patient reported