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Impact of phenylalanine on cognitive, cerebral, and neurometabolic parameters in adult patients with phenylketonuria (the PICO study): a randomized, placebo-controlled, crossover, noninferiority trial.

Roman TreppRaphaela MuriStephanie AbgottsponLenka BosanskaMichel HochuliJohannes SlotboomChristian RummelRoland KreisRegula Everts
Published in: Trials (2020)
The study is registered at clinicaltrials.gov (NCT03788343) on the 27th of December 2018, at kofam.ch (SNCTP000003117) on the 17th of December 2018, and on the International Clinical Trials Registry Platform of the WHO.
Keyphrases
  • clinical trial
  • phase ii
  • phase iii
  • study protocol
  • double blind
  • squamous cell carcinoma
  • open label
  • high throughput
  • brain injury
  • room temperature