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Formation and clinical effects of anti-drug antibodies against biologics in psoriasis treatment: An analysis of current evidence.

Xiaoying SunZiyang CuiQingyun WangLiu LiuXiaojie DingJiao WangXiaoce CaiBin LiXin Li
Published in: Autoimmunity reviews (2024)
Among the 11 biologics, secukinumab, etanercept, and brodalumab resulted in the lowest ADA formation rates. Immunogenicity contributes to lower biological efficacy and a higher likelihood of injection-site reactions. Low doses, intermittent treatment may increase ADA formation. An appropriate biologic should be selected based on the ADA formation rate and course of treatment.
Keyphrases
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  • disease activity