How to differentiate induced pluripotent stem cells into sensory neurons for disease modelling: a functional assessment.

Anil Kumar KaliaCorinna RösselerRafael Granja-VazquezAyesha AhmadJoseph J PancrazioAnika NeureiterMei ZhangDaniel SauterIrina VetterAsa AnderssonGregory DussorTheodore J PriceBenedict J KolberVincent TruongPatrick WalshAngelika Lampert

Published in: Stem cell research & therapy (2024)

We validated the efficiency of two differentiation protocols and their potential application for functional assessment and thus understanding the disease mechanisms from patients suffering from pain disorders. We propose that both differentiation methods can be further exploited for understanding mechanisms and development of novel treatments in pain disorders.

Keyphrases

chronic pain
induced pluripotent stem cells
end stage renal disease
pain management
neuropathic pain
ejection fraction
newly diagnosed
spinal cord
peritoneal dialysis
prognostic factors
spinal cord injury
risk assessment
human health