Our efforts to develop potent anti-inflammatory and antioxidant agents having a preeminent activity in the search to find novel therapies for treating inflammation and oxidation. Imidazo-thiadiazoles 5a, 5e as well as 5f showed potential anti-inflammatory activity. All tested imidazo-thiadiazole derivatives (5a-f) were showed potential antioxidant activity against one more radical scavenging species as compared to ascorbic acid as reference standard. Thus, imidazo-thiadiazole derivatives constitute an interesting template for design and development new antioxidant as well as anti-inflammatory agents.