Epigenome-Wide Study Identifies Epigenetic Outliers in Normal Mucosa of Patients with Colorectal Cancer.
Jayashri GhoshBryant M SchultzJoe ChanClaudia WultschRajveer SinghImad ShureiqiStephanie ChowAhmet DoymazSophia VarrianoMelissa DriscollJennifer MuseFrida Esther KleimanKonstantinos KrampisJean-Pierre J IssaCarmen SapienzaPublished in: Cancer prevention research (Philadelphia, Pa.) (2022)
Our study identifies an epigenetically distinct OMP group in the normal mucosa of patients with colorectal cancer that is characterized by a disrupted methylome, altered gene expression, and microbial dysbiosis. Identification of OMPs in healthy controls and patients with colorectal cancer will lead to prevention and better prognosis, respectively.