Elevated levels of circulating mitochondrial DNA predict early allograft dysfunction in patients following liver transplantation.

Osamu Yoshino Boris Ka Leong Wong Daniel Robert Anthony Cox Eunice G Lee Graham Hepworth Christopher Christophi Robert Jones Alexander Dobrovic Vijayaragavan Muralidharan Marcos Vinicius Perini

Published in: Journal of gastroenterology and hepatology (2021)

The early release of plasma cmtDNA is strongly associated with hepatocellular damage; however, the late surge in cmtDNA in patients with EAD appeared to be independent of hepatocellular injury as measured by conventional tests.

Keyphrases

mitochondrial dna
end stage renal disease
copy number
oxidative stress
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
gene expression
dna methylation