Liver injury after SARS-CoV-2 vaccination: Features of immune-mediated hepatitis, role of corticosteroid therapy and outcome.
Cumali EfeAnand V KulkarniBenedetta Terziroli Beretta PiccoliBianca MagroAlbert StättermayerMustafa CengizDaniel I Clayton-ChubbCraig Steven LammertChristine BernsmeierÖzlem GülFatima Higuera-de la TijeraMargarita AndersEllina LytvyakMete AkınTugrul PurnakRodrigo LiberalMirta PeraltaBerat EbikSerkan DumanNurhan DemirH. Yasemin BalabanÁlvaro UrzúaFernando ContrerasMaria Grazia VenturelliYılmaz BilgiçAdriana MedinaMarcos GiralaFulya GünşarMaría Carlota LondoñoTheodoros AndroutsakosAyelen KischAlper YurciFatih GüzelbulutYasir Furkan ÇağınEnver AvcıMurat AkyıldızEmine Kübra Dindar-DemirayMurat HarputluoğluRahul KumarSanjaya Kumar SatapathyManuel MendizabalMarcelo SilvaStefano FagiuoliStuart Keith RobertsNeşe Karadağ SoyluRamazan IdilmanEric M YoshidaAldo J Montano-LozaGeorge N DalekosViviana E RéThomas D SchianoStaffan WahlinPublished in: Hepatology (Baltimore, Md.) (2022)
SARS-CoV-2 vaccination can be associated with liver injury. Corticosteroid therapy may be beneficial in those with immune-mediated features or severe hepatitis. Outcome was generally favorable, but vaccine-associated liver injury led to fulminant liver failure in one patient.