Binding Immunoglobulin Protein (BIP) Inhibits TNF-α-Induced Osteoclast Differentiation and Systemic Bone Loss in an Erosive Arthritis Model.

Mario M ZaissChristopher HallNeil W A McGowanRebecca BabbVikesh DevliaSébastien LucasSajeda MeghjiBrian HendersonAline BozecGeorg SchettJean-Pierre DavidGabriel S PanayiAgamemnon E GrigoriadisValerie M Corrigall

Published in: ACR open rheumatology (2019)

BiP combines an anti-inflammatory function with antiosteoclast activity, which establishes it as a potential novel therapeutic for inflammatory disorders associated with bone loss.

Keyphrases

bone loss
rheumatoid arthritis
anti inflammatory
diabetic rats
high glucose
binding protein
oxidative stress
drug induced
protein protein
amino acid
risk assessment
small molecule
climate change
stress induced