Germline pathogenic variants associated with triple-negative breast cancer in US Hispanic and Guatemalan women using hospital and community-based recruitment strategies.
Jesica M Godinez ParedesIsabel RodriguezMegan RenAnali OrozcoJeremy OrtizAnaseidy AlbanezCatherine JonesZeina NahlehLilian BarredaLisa GarlandEdmundo Torres-GonzalezDongjing WuWen LuoJia LiuVictor ArguetaRoberto OrozcoEduardo GharzouziMichael DeanPublished in: Breast cancer research and treatment (2024)
Guatemalan and US Hispanic women have rates of hereditary breast cancer pathogenic variants similar to other populations and are more likely to have early age at diagnosis, a family history, and a more aggressive disease. Patient recruitment was higher using hospital-based versus community enrollment. This data supports genetic testing in breast cancer patients to reduce breast cancer mortality in Hispanic women.
Keyphrases
- polycystic ovary syndrome
- breast cancer risk
- healthcare
- pregnancy outcomes
- african american
- cervical cancer screening
- copy number
- mental health
- cardiovascular events
- electronic health record
- cardiovascular disease
- insulin resistance
- metabolic syndrome
- big data
- health insurance
- risk factors
- deep learning
- adverse drug
- genetic diversity