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PODO447: a novel antibody to a tumor-restricted epitope on the cancer antigen podocalyxin.

Diana Canals HernaezMichael R HughesPamela DeanPeter BergqvistIsmael SamudioOla BlixtKatharina WiedemeyerYicong LiChris BondEric CruzMartin KöbelBlake GilksCalvin D RoskelleyKelly M McNagny
Published in: Journal for immunotherapy of cancer (2021)
We have generated a novel and exquisitely tumor-restricted mAb, PODO447, that recognizes a glycoepitope on Podxl expressed at high levels by a variety of tumors including the majority of life-threatening high-grade serous ovarian tumors. Thus, tumor-restricted PODO447 exhibits the appropriate specificity for further development as a targeted immunotherapy.
Keyphrases
  • high grade
  • papillary thyroid
  • squamous cell carcinoma
  • monoclonal antibody
  • drug delivery