Serendipitous discovery of light-induced (In Situ) formation of an Azo-bridged dimeric sulfonated naphthol as a potent PTP1B inhibitor.

Robert D BongardMichael LepleyKhushabu ThakurMarat R TalipovJaladhi NayakRachel A Jones LipinskiChris BohlNoreena SweeneyRamani RamchandranRajendra RathoreDaniel S Sem

Published in: BMC biochemistry (2017)

We report the identification of a potent PTP1B inhibitor that was initially identified in a screen for DUSP5, implying common mechanism of inhibitory action for these scaffolds.

Keyphrases

high throughput
small molecule
anti inflammatory
bioinformatics analysis