In vivo Raman spectroscopy study on the stimulation mechanism of surfactant.
Yifan HeWenhai WuJing LiYouting LiuZhaohui QuYuhong LiuPublished in: Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) (2020)
The damage to the surface of normal skin by SDS was visible from the photographs taken by skin magnifier, and the apparent damage matched the damage that was happening underneath the skin elucidated by Raman spectra. Compared to the normal skin, the inter-cellular lipids (ICL) lateral packing order of the damaged skin was significantly reduced in 2-12 μm of skin depth (P < 0.05), deeper than 12 μm was not detected. The skin depth of 0-2 μm could not be determined due to strong interference of SDS. Significant change in the secondary and tertiary structures of keratin was not found.