Environmental risks and sphingolipid signatures in adult asthma and its phenotypic clusters: a multicentre study.

Chao-Chien WuChin-Chou WangWen-Yu ChungChau-Chyun SheuYi-Hsin YangMing-Yen ChengRuay-Sheng LaiSum-Yee LeungChi-Cheng LinYu-Feng WeiChing-Hsiung LinSheng-Hao LinJeng-Yuan HsuWei-Chang HuangChia-Cheng TsengYung-Fa LaiMeng-Hsuan ChengHuang-Chi ChenChih-Jen YangShih-Chang HsuChian-Heng SuChien-Jen WangHuei-Ju LiuHua-Ling ChenYuan-Ting HsuChih-Hsing HungChon-Lin LeeMing-Shyan HuangShau-Ku Huang

Published in: Thorax (2022)

These results suggest the potential contribution of environmental factors from multiple sources, their ensuing oxidative stress and sphingolipid remodeling to adult asthma and its phenotypic heterogeneity.

Keyphrases

human health
chronic obstructive pulmonary disease
oxidative stress
lung function
allergic rhinitis
risk assessment
single cell
dna damage
drinking water
childhood cancer
genome wide
ischemia reperfusion injury
young adults
gene expression
endoplasmic reticulum stress
heat shock protein