Recent Advances and Challenges in Cancer Immunotherapy.
Chelsea M PetersonNathan DenlingerYiping YangPublished in: Cancers (2022)
Cancer immunotherapy has revolutionized the field of oncology in recent years. Harnessing the immune system to treat cancer has led to a large growth in the number of novel immunotherapeutic strategies, including immune checkpoint inhibition, chimeric antigen receptor T-cell therapy and cancer vaccination. In this review, we will discuss the current landscape of immuno-oncology research, with a focus on elements that influence immunotherapeutic outcomes. We will also highlight recent advances in basic aspects of tumor immunology, in particular, the role of the immunosuppressive cells within the tumor microenvironment in regulating antitumor immunity. Lastly, we will discuss how the understanding of basic tumor immunology can lead to the development of new immunotherapeutic strategies.
Keyphrases
- cell therapy
- papillary thyroid
- palliative care
- squamous cell
- induced apoptosis
- stem cells
- mesenchymal stem cells
- squamous cell carcinoma
- big data
- type diabetes
- metabolic syndrome
- signaling pathway
- machine learning
- skeletal muscle
- adipose tissue
- cell proliferation
- single cell
- deep learning
- childhood cancer
- oxidative stress
- weight loss