Delivery of Conjugated Silicon Dioxide Nanoparticles Show Strong Anti-Proliferative Activities.
Sarah Mousa AsiriSarah Mousa AsiriAyhan BozkurtPublished in: Applied biochemistry and biotechnology (2019)
Conjugation of different molecules is a promising approach to enhance the drug delivery and treatment. In the present study, here, we have synthesized silica oxide (SiO2) nanoparticles conjugated with (3-Glycidyloxypropyl) trimethoxysilane (3GPS) and further reacted with 1,2,4-triazole (Tri), 3-aminotriazole (ATri), 5-aminetetrazole (Atet), imidazole (Imi). The structure, size, and morphology of nanocomposite materials were characterized by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), transmission electron microscopy (TEM), and scanning electron microscopy (SEM) methods. These nanocomposite materials were tested on human colorectal carcinoma cells (HCT-116) to examine their anti-cancer capabilities by using MTT assay and morphometric analysis. Our results revealed that nanocomposite materials decreased cancer cell viability and cell proliferation and caused cell death in a concentration-dependent manner. Our findings demonstrate that SiO2-conjugated nanocomposite materials possess strong anti-cancer capabilities and hold a great potential for the colon cancer treatments.
Keyphrases
- electron microscopy
- reduced graphene oxide
- cell death
- drug delivery
- cell proliferation
- photodynamic therapy
- quantum dots
- carbon nanotubes
- solid phase extraction
- endothelial cells
- high throughput
- highly efficient
- papillary thyroid
- high resolution
- gold nanoparticles
- cell cycle
- squamous cell carcinoma
- young adults
- single cell
- oxide nanoparticles
- tandem mass spectrometry
- simultaneous determination
- smoking cessation
- walled carbon nanotubes