Superoxide Dismutase Mimic, MnTE-2-PyP Enhances Rectal Anastomotic Strength in Rats after Preoperative Chemoradiotherapy.

Yu YangQi WangJiajun LuoYue JiangRui ZhouShilun TongZhihua WangQiang Tong

Published in: Oxidative medicine and cellular longevity (2020)

MnTE-2-PyP enhanced intestine anastomotic strength in rats with preoperative CRT. Specifically, MnTE-2-PyP decreased MMP levels and increased MVD in anastomosis. Therefore, MnTE-2-PyP may be helpful in the prevention of anastomotic leak after preoperative CRT.

Keyphrases

rectal cancer
locally advanced
patients undergoing
cardiac resynchronization therapy
heart failure
hydrogen peroxide
radiation therapy
cell migration