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Green Chemistry for Crosslinking Biopolymers: Recent Advances in Riboflavin-Mediated Photochemistry.

Yoon Bok LeeSaebin LimYerin LeeChan Ho ParkHyun-Jong Lee
Published in: Materials (Basel, Switzerland) (2023)
Riboflavin (RF), which is also known as vitamin B2, is a water-soluble vitamin. RF is a nontoxic and biocompatible natural substance. It absorbs light (at wavelengths of 380 and 450 nm) in the presence of oxygen to form reactive singlet oxygen ( 1 O 2 ). The generated singlet oxygen acts as a photoinitiator to induce the oxidation of biomolecules, such as amino acids, proteins, and nucleotides, or to initiate chemical reactions, such as the thiol-ene reaction and crosslinking of tyramine and furfuryl groups. In this review, we focus on the chemical mechanism and utilization of the photochemistry of RF, such as protein crosslinking and hydrogel formation. Currently, the crosslinking method using RF as a photoinitiator is actively employed in ophthalmic clinics. However, a significant broadening is expected in its range of applications, such as in tissue engineering and drug delivery.
Keyphrases
  • tissue engineering
  • drug delivery
  • water soluble
  • amino acid
  • primary care
  • drug release
  • photodynamic therapy
  • cancer therapy
  • small molecule
  • protein protein
  • energy transfer
  • quantum dots