Role of MTHFR, IRF6, PAX7 and TP63 SNPs in susceptibility to non-syndromic orofacial cleft, a candidate gene study in a Portuguese population.

João Mendes Adriana Rocha Guimarães Joana Martins Ribeiro Bárbara Cecília Bessa Dos Santos Oliveiros Paiva Luís Alcides Mesquita Maria Helena Raposo Fernandes Francisco José Fernandes do Vale Henriqueta Coimbra Silva

Published in: Orthodontics & craniofacial research (2024)

In this Portuguese population, there was no evidence of an association between the evaluated SNPs and NSOC. For TP63 SNP, the possibility of a protective effect of heterozygotes should be further investigated.

Keyphrases

genome wide
dna methylation
copy number
intellectual disability
dendritic cells
mass spectrometry
autism spectrum disorder
gene expression
high density
transcription factor