Impact of Atherosclerosis- and Diabetes-Related Dicarbonyls on Vascular Endothelial Permeability: A Comparative Assessment.
Mikhail V SamsonovAsker Y KhapchaevAlexander V VorotnikovTatyana N VlasikElena V YanushevskayaMaria V SidorovaEvgeniy E EfremovVadim Z LankinVladimir P ShirinskyPublished in: Oxidative medicine and cellular longevity (2017)
Our comparative study demonstrates that MDA is more damaging to the endothelial barrier than GO or MGO. Considering that MDA endogenous levels exceed those of GO or MGO and tend to increase further during lipoperoxidation, it appears important to reduce oxidative stress and, in particular, MDA levels in order to prevent sustained vascular hyperpermeability in atherosclerosis and diabetes patients.
Keyphrases
- cardiovascular disease
- breast cancer cells
- type diabetes
- oxidative stress
- endothelial cells
- end stage renal disease
- ejection fraction
- newly diagnosed
- glycemic control
- chronic kidney disease
- cell cycle arrest
- prognostic factors
- cell death
- adipose tissue
- ischemia reperfusion injury
- cell proliferation
- patient reported outcomes
- diabetic rats
- insulin resistance