The α2 isoform Na,K-ATPase modulates contraction of rat mesenteric small artery via cSrc-dependent Ca2+ sensitization.

E V BouzinovaL HangaardC StaehrA MazurA FerreiraA V ChibalinS L SandowZ XieC AalkjaerVladimir V Matchkov

Published in: Acta physiologica (Oxford, England) (2018)

Data suggest that micromolar ouabain potentiates agonist-induced contraction of rat mesenteric small artery via Na,K-ATPase-dependent cSrc activation, which increases Ca2+ sensitization of vascular smooth muscle cells by MYPT1 phosphorylation. This mechanism may be critical for acute control of vascular tone.

Keyphrases

vascular smooth muscle cells
protein kinase
angiotensin ii
oxidative stress
drug induced
smooth muscle
liver failure
diabetic rats
high glucose
endoplasmic reticulum
aortic dissection
machine learning
data analysis