Concurrent administration with multivalent metal cation preparations or polycationic polymer preparations inhibits the absorption of raltegravir via its chelation.
Yuki EnokiNorihiro SuzukiMotoyasu ItoEri UchiyamaNagomi KishiChihiro ItoYuki KitahiroKazuki SakamotoKazuaki TaguchiYuta YokoyamaJunko KizuKazuaki MatsumotoPublished in: The Journal of pharmacy and pharmacology (2020)
The interaction of RAL with Al(OH)3 , LaCO3, Bxl, or Svl can inhibit RAL absorption into the gastrointestinal tract, and thus, the multivalent metal cation and polycationic polymer are the modifying factors that can affect RAL pharmacokinetics.