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Assessing the Causal Relationships Between Insulin Resistance and Hyperuricemia and Gout Using Bidirectional Mendelian Randomization.

Natalie McCormickMark J O'ConnorChio YokoseTony Raymond MerrimanDavid B MountAaron LeongHyon K Choi
Published in: Arthritis & rheumatology (Hoboken, N.J.) (2021)
These findings provide evidence to clarify core questions about the close association between hyperuricemia and insulin resistance syndrome: hyperinsulinemia leads to hyperuricemia but not the other way around. Reducing insulin resistance could lower the SU level and gout risk, whereas lowering the SU level (e.g., allopurinol treatment) is unlikely to mitigate insulin resistance and its cardiometabolic sequelae.
Keyphrases
  • insulin resistance
  • uric acid
  • metabolic syndrome
  • adipose tissue
  • high fat diet
  • polycystic ovary syndrome
  • skeletal muscle
  • type diabetes
  • high fat diet induced
  • glycemic control
  • combination therapy
  • weight loss