The Direct and Long-Term Effects of Raloxifene as Adjunctive Treatment for Schizophrenia-Spectrum Disorders: A Double-Blind, Randomized Clinical Trial.

Bodyl A Brand Janna N de BoerMachteld C MarcelisKoen P GrootensJurjen J LuykxIris E Sommer

Published in: Schizophrenia bulletin (2023)

Our results do not support the use of raloxifene in patients with SSD in general, but suggest female-specific beneficial effects of raloxifene on negative symptoms and working memory. Our findings encourage further research on sex-specific pharmacotherapeutic treatment.

Keyphrases

working memory
depressive symptoms
attention deficit hyperactivity disorder
combination therapy
transcranial direct current stimulation
sleep quality