A novel genomic panel as an adjunctive diagnostic tool for the characterization and profiling of breast Fibroepithelial lesions.

Yirong R SimGwendolene Xin Pei NgCedric Chuan Young NgVikneswari RajasegaranSuet Far WongWei LiuPeiyong GuanSanjanaa NagarajanWai Yee NgAye Aye ThikeJeffrey Chun Tatt LimNur Diyana Binte Md NasirVeronique Kiak Mien TanPreetha MadhukumarWei Sean YongChow Yin WongBenita Kiat Tee TanKong Wee OngBin Tean TehPuay Hoon Tan

Published in: BMC medical genomics (2019)

This novel study demonstrates the ability to extract DNA of sufficient quality and quantity for targeted sequencing from FFPE breast core biopsy specimens, along with their successful characterization and profiling using our customized 16-gene panel. Prospective work includes validating the utility of this promising 16-gene panel assay as an adjunctive diagnostic tool in clinical practice.

Keyphrases

copy number
single cell
clinical practice
genome wide
genome wide identification
high throughput
fine needle aspiration
oxidative stress
circulating tumor
single molecule
dna methylation
drug delivery
quality improvement