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Polyacetylenic Oleanane-Type Triterpene Saponins from the Roots of Panax japonicus.

Yang LiuJianping ZhaoYang ChenWei LiBin LiYuqing JianGulnar SabirShaowu ChengQinhui TuoIkhlas KhanWei Wang
Published in: Journal of natural products (2016)
Three new polyacetylenic oleanane-type triterpenoids, baisanqisaponins A-C (1-3), and one new oleanane-type triterpenoid, chikusetsusaponin-V ethyl ester (4), together with 19 known compounds (5-23), were isolated from the roots of Panax japonicus. The structures were elucidated on the basis of spectroscopic analyses and chemical methods. Compounds 1-3 feature a rare panaxytriol group containing a polyacetylene on the saponin skeleton. Neuroprotective activity was evaluated for compounds 1-17, and angiotensin II-induced vascular smooth muscle cell proliferation inhibition was tested for compounds 5-7 and 10-12.
Keyphrases
  • angiotensin ii
  • smooth muscle
  • cell proliferation
  • vascular smooth muscle cells
  • machine learning
  • high resolution
  • molecular docking
  • diabetic rats
  • drug induced
  • brain injury
  • cerebral ischemia
  • subarachnoid hemorrhage