Placental imprinting of SLC22A3 in the IGF2R imprinted domain is conserved in therian mammals.

Teruhito Ishihara Oliver W Griffith Shunsuke Suzuki Marilyn B Renfree

Published in: Epigenetics & chromatin (2022)

Since SLC22A3 is imprinted in the tammar placenta, we conclude that this placental imprinting of SLC22A3 has been positively selected after the marsupial and eutherian split because of the differences in the DMR location. Since SLC22A3 is known to act as a transporter molecule for nutrient transfer in the eutherian placenta, we suggest it was strongly selected to control the balance between supply and demand of nutrients in marsupial as it does in eutherian placentas.

Keyphrases

solid phase extraction
transcription factor
heavy metals
binding protein
risk assessment
cell proliferation
simultaneous determination