Enhancing the antischistosomal activity of carvacryl acetate using nanoemulsion.
Rafael L de SouzaAna C MengardaDaniel B RoquiniCamila de Oliveira MeloMayara Castro de MoraisMaria Cristina C Espírito-SantoDamião Pergentino de SousaJosué de MoraesElquio Eleamen OliveiraPublished in: Nanomedicine (London, England) (2023)
Aim: To formulate a carvacryl acetate nanoemulsion (CANE) and test its antischistosomal activity. Materials & methods: CANE was prepared and tested in vitro on Schistosoma mansoni adult worms and both human and animal cell lines. Next, CANE was administered orally to mice infected with either a prepatent infection or a patent infection of S. mansoni . Results: CANE was stable during 90 days of analysis. CANE showed in vitro anthelmintic activity, and no cytotoxic effects were observed. In vivo , CANE was more effective than the free compounds in reducing worm burden and egg production. Treatment with CANE was more effective for prepatent infections than praziquantel. Conclusion: CANE improves antiparasitic properties and may be a promising delivery system for schistosomiasis treatment.