Nano drug-delivery systems for management of AIDS: liposomes, dendrimers, gold and silver nanoparticles.
Fateme Davarani AslMarziyeh MousazadehShirinsadat TajiAbbas BahmaniPatricia KhashayarMostafa AzimzadehEbrahim MostafaviPublished in: Nanomedicine (London, England) (2023)
AIDS causes increasing mortality every year. With advancements in nanomedicine, different nanomaterials (NMs) have been applied to treat AIDS and overcome its limitations. Among different NMs, nanoparticles (NPs) can act as nanocarriers due to their enhanced solubility, sustained release, targeting abilities and facilitation of drug-dose reductions. This review discusses recent advancements in therapeutics for AIDS/HIV using various NMs, mainly focused on three classifications: polymeric, liposomal and inorganic NMs. Polymeric dendrimers, polyethylenimine-NPs, poly(lactic-co-glycolic acid)-NPs, chitosan and the use of liposomal-based delivery systems and inorganic NPs, including gold and silver NPs, are explored. Recent advances, current challenges and future perspectives on the use of these NMs for better management of HIV/AIDS are also discussed.
Keyphrases
- antiretroviral therapy
- silver nanoparticles
- hiv aids
- drug delivery
- hiv infected
- cancer therapy
- hiv positive
- human immunodeficiency virus
- drug release
- oxide nanoparticles
- cardiovascular events
- hepatitis c virus
- small molecule
- type diabetes
- emergency department
- cardiovascular disease
- risk factors
- men who have sex with men
- hiv testing
- drug induced