The Hepatokine RBP4 Links Metabolic Diseases to Articular Inflammation.
Andrés Pazos-PérezMaría Piñeiro-RamilEloi Franco-TrepatAna Alonso-PérezMaría Guillán-FrescoAntía Crespo-GolmarMiriam López-FagúndezJavier Conde ArandaSusana Belen BravoAlberto Jorge de MoraRodolfo GomezPublished in: Antioxidants (Basel, Switzerland) (2024)
This study identifies relevant RBP4 concentrations in CA patients' synovial fluids, linking them to hypertensive patients with a metabolic disruption. Evidence is provided that RBP4 acts as a DAMP at these concentrations, inducing robust inflammatory, catabolic, chemotactic, and metabolic responses in chondrocytes, synoviocytes, and neutrophils. These effects may explain RBP4-related metabolic diseases' contribution to joint destruction in various rheumatic conditions like CA.