Bilirubin and bile acids in osteocytes and bone tissue. Potential role in the cholestatic-induced osteoporosis.

Silvia Ruiz-GaspàNuria GuanabensSusana JuradoAndreu CombaliaPilar PerisAna MonegalAlbert Parés

Published in: Liver international : official journal of the International Association for the Study of the Liver (2020)

Bilirubin and LCA have damaging consequences in osteocytes by decreasing viability, differentiation and mineralization, increasing apoptosis and modifying gene expression, effects that are neutralized by UDCA.

Keyphrases

gene expression
bone mineral density
liver injury
drug induced
postmenopausal women
oxidative stress
diabetic rats
high glucose
dna methylation
endoplasmic reticulum stress
cell cycle arrest
cell death
body composition
soft tissue
endothelial cells
signaling pathway