Epigenome-wide association study of prostate cancer in African American men identified differentially methylated genes.
Anders E BerglundKosj YamoahSteven A EschrichRana FalahatJames J MuléSungjune KimJaime MattaJulie DutilGilberto Ruiz-DeyaCarmen Ortiz SanchezLiang WangHyun ParkHirendra N BanerjeeTamara LotanKathryn Hughes BarryRyan M PutneySeung Joon KimClement GwedeJacob K KresovichYoungchul KimHui-Yi LinJasreman DhillonRatna ChakrabartiJong Y ParkPublished in: Cancer medicine (2024)
Several differentially methylated genes involved in immune-oncologic pathways associated with disease risk or aggressiveness were identified. In addition, 261 African American-specific differentially methylated genes related to the risk of PCa were identified. These results can shedlight on potential mechanisms contributing to PCa disparities in the African American Population.