Point mutation L116R in interferon-regulatory factor 4 differentially impacts key cytokine production in Th2, Th9, and Th17 cells.

IRF4 knock-out cells do not differentiate properly into T helper subsets 2, 9, and 17. Compared to WT IRF4 point mutation L116R shows differentially expressed key cytokines. While amounts Th2 and Th17 cells are decreased, there is a strong induction of Th9 cells in cells carrying the L116R mutated IRF4.