Exploring serum and immunoglobulin G N-glycome as diagnostic biomarkers for early detection of breast cancer in Ethiopian women.
Abrha G GebrehiwotDaniel Seifu MelkaYimenashu Mamo KassayeTufa GemechuWajana LakoHiroshi HinouShin-Ichiro NishimuraPublished in: BMC cancer (2019)
Our comprehensive study has addressed for the first time both whole serum and IgG N-glycosylation signatures of native black women suffering from BC and revealed novel glyco-biomarkers with marked overexpression and distinguishing ability at early stage patients. Further studies on direct identification of the intact glycoproteins using a glycoprteomics approach will provide a deeper understanding of specific biomarkers towards their clinical utility.
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