SOST, an LNGFR target, inhibits the osteogenic differentiation of rat ectomesenchymal stem cells.

Gang LiJunyu LiuManzhu ZhaoYingying WangKun YangChang LiuYong XiaoXiujie WenLuchuan Liu

Published in: Cell proliferation (2017)

SOST alleviated the osteogenic differentiation of EMSCs, and LNGFR enhanced the osteogenic differentiation of EMSCs by decreasing SOST, suggesting that the LNGFR/SOST pathway may be a novel target for promoting dental tissue regeneration and engineering.

Keyphrases

stem cells
oxidative stress
oral health
cell therapy
mesenchymal stem cells
wound healing