Programming by Methyl Donor Deficiency during Pregnancy and Lactation Produces Cardiomyopathy in Adult Rats Subjected to High Fat Diet.

Zhen LiViola J KosgeiAnais BisonJean-Marc AlbertoRemi UmoretFatiha MaskaliLaurent BrunaudJean-Louis GuéantRosa-Maria Guéant-Rodriguez

Published in: Molecular nutrition & food research (2021)

Developmental programming by iMDD produces cardiomyopathy in female offspring exposed to HF. The cardiomyopathy is linked to inflammation and fibrosis through angiotensin-AT2 and TGFB1 pathways and alteration of energy metabolism.

Keyphrases

high fat diet
heart failure
insulin resistance
adipose tissue
oxidative stress
human milk
metabolic syndrome
angiotensin converting enzyme
atrial fibrillation