Sex specificity of pancreatic cancer cachexia phenotypes, mechanisms, and treatment in mice and humans: role of Activin.

Xiaoling ZhongAshok NarasimhanLibbie M SilvermanAndrew R YoungSafi ShahdaSheng LiuJun WanYunlong LiuLeonidas G KoniarisTeresa A Zimmers

Published in: Journal of cachexia, sarcopenia and muscle (2022)

Pancreatic ductal adenocarcinoma cachexia displays sex-specific phenotypes in mice and humans, with Activin a preferential driver of muscle wasting in males. Sex is a major modulator of cachexia mechanisms. Consideration of sexual dimorphism is essential for discovery and development of effective treatments.

Keyphrases

high fat diet induced
small molecule
skeletal muscle
insulin resistance
high throughput
wild type
adipose tissue
replacement therapy