Tau accumulation and atrophy predict amyloid independent cognitive decline in aging.
Corrina S FonsecaSuzanne L BakerLindsey DobynsMustafa JanabiWilliam J JagustTheresa M HarrisonPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
Entorhinal tau change was associated with memory decline in older adults (OA), regardless of amyloid beta (Aβ). Greater meta-region of interest (ROI) tau change correlated with memory decline in Aβ+ OA. Voxel-wise temporal tau change correlated with memory decline, regardless of Aβ. Meta-ROI tau and global amyloid change correlated with non-memory change in Aβ+ OA. Tau and amyloid accumulation were not associated with structural change in OA.