Risk Factors for Nephrotoxicity in Methicillin-Resistant Staphylococcus aureus Bacteraemia: A Post Hoc Analysis of the CAMERA2 Trial.

Amy LeggNiamh MeagherSandra A JohnsonMatthew A RobertsAlan CassMarc H ScheetzJane DaviesJason Alexander RobertsJoshua S DavisSteven Y C Tong

Published in: Clinical drug investigation (2022)

For participants receiving vancomycin for S. aureus bacteraemia, use of (flu)cloxacillin and increased vancomycin area under the concentration-time curve were risk factors for acute kidney injury. These represent potentially modifiable risk factors for nephrotoxicity and highlight the importance of avoiding the use of concurrent nephrotoxins.

Keyphrases

methicillin resistant staphylococcus aureus
acute kidney injury
staphylococcus aureus
drug induced
cardiac surgery
study protocol
phase iii
clinical trial
phase ii
locally advanced
high speed
convolutional neural network
machine learning
open label
high resolution
double blind