Positive-Charge Functionalized Mesoporous Silica Nanoparticles as Nanocarriers for Controlled 2,4-Dichlorophenoxy Acetic Acid Sodium Salt Release.
Li-Dong CaoZhaolu ZhouShujun NiuChong CaoXiuhuan LiYongpan ShanQi-Liang HuangPublished in: Journal of agricultural and food chemistry (2017)
Because of its relatively high water solubility and mobility, 2,4-dichlorophenoxy acetic acid (2,4-D) has a high leaching potential threatening the surface water and groundwater. Controlled release formulations of 2,4-D could alleviate the adverse effects on the environment. In the present study, positive-charge functionalized mesoporous silica nanoparticles (MSNs) were facilely synthesized by incorporating trimethylammonium (TA) groups onto MSNs via a postgrafting method. 2,4-D sodium salt, the anionic form of 2,4-D, was effectively loaded into these positively charged MSN-TA nanoparticles. The loading content can be greatly improved to 21.7% compared to using bare MSNs as a single encapsulant (1.5%). Pesticide loading and release patterns were pH, ionic strength and temperature responsive, which were mainly dominated by the electrostatic interactions. Soil column experiments clearly demonstrated that MSN-TA can decrease the soil leaching of 2, 4-D sodium salt. Moreover, this novel nanoformulation showed good bioactivity on target plant without adverse effects on the growth of nontarget plant. This strategy based on electrostatic interactions could be widely applied to charge carrying agrochemicals using carriers bearing opposite charges to alleviate the potential adverse effects on the environment.
Keyphrases
- heavy metals
- cancer therapy
- human health
- drug delivery
- risk assessment
- solar cells
- quantum dots
- molecular dynamics simulations
- adverse drug
- municipal solid waste
- health risk assessment
- sewage sludge
- health risk
- drinking water
- molecularly imprinted
- liquid chromatography
- ionic liquid
- drug release
- mass spectrometry
- cell wall
- simultaneous determination