Association of MTHFR Polymorphisms With Leukoencephalopathy Risk in Primary CNS Lymphoma Patients Treated With Methotrexate-Based Regimens.
Philipp KarschniaSylvia C KurzPriscilla Kaliopi BrastianosSebastian F WinterAmanda GordonSooAe JonesMichelle PisapiaNaema NayyarJoerg-Christian TonnTracy T BatchelorScott R PlotkinJorg DietrichPublished in: Neurology (2023)
1298A→C genotype may serve to identify PCNSL patients at elevated risk for HD-MTX-induced leukoencephalopathy. This appears to translate into reduced survival, potentially due to decreased functional status.