Alkylverdazyls as a Source of Alkyl Radicals for Light-Triggered Cancer Cell Death.
Darya E VotkinaEvgenii V PlotnikovPavel V PetuninElizaveta S BerdinskayaMaria S TretyakovaGérard AudranSylvain R A MarquePavel S PostnikovPublished in: Molecular pharmaceutics (2021)
Two alkylated verdazyl radicals (AlkVZs) were investigated as active compounds for photoinitiated controlled MCF-7 cell death. Observed results unambiguously showed that AlkVZ could be a potential structural moiety for the design of a novel family of photodynamic therapy agents. The main advantage of the proposed substances is an oxygen-independent generation of active radicals, which play a pivotal role in the treatment of oxygen-deficient tumors.